ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

γ-Oxocarboxylic Acids in Heterocyclic Synthesis IV. Synthesis of Some Pyridazines Containing Phthalyl- and Tosylamino Acids Using Dicyclohexylcarbodiimide as the Condensing Agent

A. A. Aly and A. A. F. Wasfy

Department of Chemistry, Faculty of Science, Benha University, Benha, Egypt

E-mail: wasfya@hotmail.com

Received: 17 September 2002

Abstract: 3(2H)-Oxo-, 3(2H)-thioxo- or 3-aminopyridazine derivatives were coupled with N-phthalyl- or N-tosylamino acids in one-step room-temperature reaction using N,N
-dicyclohexylcarbodiimide as the condensing agent to furnish the corresponding 3-N-(phthalyl- or tosylamino acids) pyridazine derivatives. Hydrazinolysis of the N-phthalyl derivatives in methanol yielded the corresponding unprotected derivatives. The antibacterial activities of the prepared compounds were tested.

Full paper in Portable Document Format: 582a126.pdf

Chemical Papers 58 (2) 126–132 (2004)