ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Voltammetric Determination of Labetalol in Pharmaceuticals and Spiked Human Urine

A. Radi, Z. El-Sherif, and A. Wassel

Department of Chemistry, Faculty of Science, Mansoura University, 34517 Dumyat, Egypt

E-mail: abdradi@yahoo.com

Received: 19 May 2003

Abstract: The electrochemical oxidation of labetalol was investigated by cyclic, linear sweep and differential pulse voltammetry at carbon paste electrode in Britton—Robinson buffers over the pH range 2.0—10.0. For analytical purposes, a well-defined adsorption-controlled anodic peak was obtained in Britton—Robinson buffer at pH 2.0. By anodic adsorptive linear sweep and differential pulse voltammetry, linear calibration plots were obtained in the ranges of 2.5 × 10⁻⁶—1.0 × 10⁻⁵ mol dm⁻³ and 2.5×10⁻⁸—1.0 × 10⁻⁵ mol dm⁻³ for both techniques, respectively. Detection limits were found 1.0 × 10−6 mol dm⁻³ for LSV and 1.0 × 10⁻⁸ mol dm⁻³ for DPV. Based on this study, two simple, rapid, selective, and sensitive voltammetric methods were developed for the determination of labetalol in tablet dosage form. The preconcentration/medium exchange/voltammetry approach was applied for the drug determination in spiked human urine.

Full paper in Portable Document Format: 584a242.pdf

Chemical Papers 58 (4) 242–246 (2004)