ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Furan-containing thiacyanine analogs and their antimicrobial activity

I. Kortišová, P. Foltínová, and J. Halgaš

Department of Chemistry, Faculty of Natural Sciences, St. Cyril and Methodius University, SK-917 01 Trnava, Slovakia

E-mail: foltinova@m2.fedu.uniba.sk

Received: 20 December 2004  Revised: 16 November 2005  Accepted: 21 November 2005

Abstract: Condensation of quaternary 2-methylbenzothiazolium bromides with 5-(dialkylamino)furan-2-carbaldehydes afforded a series of new thiacyanine analogs. The compounds exhibit significant activities against several bacterial, yeast, and mould strains. Derivatives with dipropylamino substituents showed higher inhibitory effects than those with cyclic secondary amino groups. Hence, the biological activity may have been influenced by the lipophilicity of the compounds. The effect on growth and on the plastid system of the unicellular flagellate Euglena gracilis was also studied.

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-006-0009-9

Chemical Papers 60 (1) 52–55 (2006)