ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Voltammetric determination of phentolamine mesylate in pharmaceutical formulations at poly (4-aminobenzene sulfonic acid)-modified glassy carbon electrode

Sen Fan, Lei Ji, Guoliang Mao, Xin Sui, Huan Wang, Yuanhai Zhu, and Hua Song

College of Petroleum Engineering, Northeast Petroleum University, Daqing, People’s Republic of China

E-mail: yuanhaizhu@163.com

Received: 12 December 2019  Accepted: 12 June 2020

Abstract:

A poly (4-aminobenzene sulfonic acid)-modified glassy carbon electrode (p-ABSA/GCE) was fabricated by electropolymerization. It was found that phentolamine mesylate, an effective and important cardiovascular dilatation drug with low redox activity at the glassy carbon electrode (GCE) can produce a sensitive well-defined anodic peak current at p-ABSA/GCE. Investigation indicated that the oxidation of phentolamine at p-ABSA/GCE was one electron/one proton transfer process which was controlled by adsorption. In optimal conditions, the anodic peak current was linear to the concentrations of phentolamine over the range of 5.0 × 10^–7–1.0 × 10^–5 M with a detection limit of 2.0 × 10^–7 M. The modified electrode showed good stability and reproducibility. The electroanalytical method proposed was successfully applied to the determination of phentolamine mesylate in pharmaceutical formulations.

Keywords: Phentolamine; Electropolymerization; 4-Aminobenzene sulfonic acid; Modified glassy carbon electrode

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-020-01250-x

Chemical Papers 74 (12) 4411–4417 (2020)