ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Controlled release of anticancer drug using o-phenylenediamine functionalized SBA-15 as a novel nanocarrier

Leila Hajiaghababaei, Mahtab Eslambolipour, Alireza Badiei, Mohammad R. Ganjali, and Ghodsi M. Ziarani

Department of Chemistry, Yadegar-e-Imam Khomeini (RAH) Shahre Rey Branch, Islamic Azad University, Tehran, Iran

E-mail: lhajiaghababaei@yahoo.com

Received: 29 August 2020  Accepted: 5 November 2020

Abstract: In this study, a pH-sensitive drug delivery system was presented by o-phenylenediamine functionalized SBA-15 as a new carrier for controlled release of imatinib mesylate. O-phenylenediamine functionalized SBA-15 mesoporous silica was synthesized and characterized. Powder X-ray diffraction proved the 2D hexagonal mesostructure with p6mm space group for nanoporous materials. The o-phenylenediamine functionalized SBA-15 showed the BET surface area 265 m²g⁻¹ and pore diameter 5.8 nm, based on adsorption–desorption of N₂ at 77 ºK. The presence of organic groups in the silica framework was demonstrated by FTIR spectrum. Then, the imatinib mesylate was loaded on o-phenylenediamine functionalized SBA-15 in saturated drug aqueous solution at ambient temperature for 1 h. According to the observations on drug release in phosphate buffers, the imatinib mesylate release from o-phenylenediamine functionalized SBA-15 shows a pH-associated behavior, and the rate of imatinib mesylate release was quicker at lower pH than higher pH. In addition, the imatinib mesylate had a slow release pattern in SBF with a constant rate of approximately 1.4 µg h⁻¹ after the first hour. The results illustrated that o-phenylenediamine functionalized SBA-15 is a suitable option for being employed as a new carrier for controlled release of imatinib mesylate.

Keywords: Controlled release; Functionalized SBA-15; Imatinib mesylate; Nanocarrier; o-phenylenediamine; pH-sensitive

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-020-01422-9

Chemical Papers 75 (5) 1841–1850 (2021)