ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Bacterial cellulose/poly vinyl alcohol based wound dressings with sustained antibiotic delivery

Emel Tamahkar

Department of Bioengineering, Bursa Technical University, Bursa, Turkey

E-mail: emel.irmak@btu.edu.tr

Received: 13 November 2020  Accepted: 27 March 2021

Abstract:

The current work was aimed to prepare bacterial cellulose/poly vinyl alcohol (BC/PVA) wound dressings loaded with antibiotic which were prepared via freeze-thawing. The swelling ratio of BC/PVA hydrogels was in the range of 188–240%. The water loss percentage of BC was improved with the addition of PVA. 30% of the cumulative ampicillin delivery from BC/PVA hydrogels was achieved during 120 h suggesting significant role of PVA incorporation since 50% of ampicillin was released from BC after 24 h. BC/PVA hydrogels showed great antibacterial activity against E.coli and S. aureus. The results revealed that BC/PVA hydrogels presented great potential as wound dressings with high swelling ratio, low water loss percentage and slow antibiotic release properties.

Keywords: Bacterial cellulose nanofibers; Poly vinyl alcohol; Wound dressing; Antibiotic delivery

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-021-01631-w

Chemical Papers 75 (8) 3979–3987 (2021)