ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Kinetic and polarographic study on atropine N-oxide: its obtaining and polarographic reduction

Liliya Dubenska, Olha Dushna, Mykola Blazheyevskiy, Solomiya Pysarevska, and Iryna Klymiuk

Department of Analytical Chemistry, Ivan Franko National University of Lviv, Lviv, Ukraine

E-mail: solomiya.pysarevska@lnu.edu.ua

Received: 6 February 2021  Accepted: 1 April 2021

Abstract:

The work presents the obtaining of atropine N-oxide using various peroxyacids (organic monoperoxyacid, diperoxyacids and inorganic peroxyacids). The kinetics of atropine oxidation with various oxidants, for example Oxone, m-chloroperoxybenzoic acid, diperoxysebasic acid and diperoxyazelaic acid, was studied. The optimal conditions for obtaining of atropine N-oxide (oxidation duration, pH) are given in the work. It was established that the best oxidant was potassium peroxymonosulfate, since 100% yield of atropine N-oxide was achieved within 15 min. In this work, we showed that the oxidation reaction of atropine to N-oxide was a second-order reaction. The rate constants of these reactions were established. The electrochemical behavior of atropine N-oxide obtained using potassium peroxymonosulfate and m-chloroperoxybenzoic acid on a mercury dropping electrode was investigated. Atropine N-oxide was reduced forming two peaks. Each reduction peak involved 1 electron and 1 proton.

Keywords: Atropine; N-oxide; Peroxyacid; Kinetics; Electrochemistry

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-021-01638-3

Chemical Papers 75 (8) 4147–4155 (2021)