ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Cis-Palladium(II) complex incorporating 3-(2-pyridyl)-5-methyl-1,2,4-triazole: structure and cytotoxic activity

Borys V. Zakharchenko, Dmytro M. Khomenko, Roman O. Doroschuk, Ilona V. Raspertova, Sergiu Shova, Anna G. Grebinyk, Iryna I. Grynyuk, Svitlana V. Prylutska, Olga P. Matyshevska, Mykola S. Slobodyanik, Marcus Frohme, and Rostislav D. Lampeka

Taras Shevchenko National University of Kyiv, Kiev, Ukraine

E-mail: ilonabatyuk@gmail.com

Received: 27 January 2021  Accepted: 12 May 2021

Abstract:

The structure of complex cis-Pd(HL^Me)Cl₂ was studied both in solution and in solid state using multinuclear (¹H, ¹³C, ¹⁵N) NMR spectroscopy and X-ray structural analysis. Complex was evaluated for cytotoxic activity. Thus, the results showed that cis-Pd(HL^Me)Cl₂ has a pronounced cytotoxicity toward human leukemic lymphoblast’s CCRF-CEM and cervix adenocarcinoma HeLa cells. Moreover, it was found that cis-Pd(HL^Me)Cl₂ is more toxic than cisplatin: its IC₅₀ value at 24 h incubation was lower by more than an order for CCRF-CEM cells and by three orders for HeLa cells as compared with cisplatin IC₅₀. Depending on the concentration, cis-Pd(HL^Me)Cl₂ is accelerated or slowed hemolysis of erythrocytes. Observed differential biological effects of cis-Pd(HL^Me)Cl₂ suggest the dependence of the agent’s interactions with cells on the molecular structure of palladium ligand and the cell type.

Keywords: Palladium; 1,2,4-Triazole; NMR spectroscopy; Cytotoxicity; Cancer cells; Hemolysis of erythrocytes

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-021-01699-4

Chemical Papers 75 (9) 4899–4906 (2021)