ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

A new 2D → 3D interdigitated supramolecular compound as luminescent sensor for detection of Hg²⁺ and treatment activity on pancreatic cancer

Zhenshan Guo, Jun Zhen, Zhoujia Yao, Yemeng Wang, and Chenlu Jin

Department of Hepatobiliary Surgery, Zhuji People’s Hospital of Zhejiang Province, Zhuji, China

E-mail: chenlu_jin11@126.com

Received: 26 March 2021  Accepted: 15 May 2021

Abstract:

A novel Zn(II) coordination polymer, i.e., [Zn(L)_0.5(phen)]_n·n(H₂O) (1, where phen is 1,10-phenanthroline and H₄L is 5,5’-(1,4-phenylenebis(methylene))bis(oxy)diisophthalic acid), was generated with the solvothermal reactions between phen, H₄L and Zn(NO₃)₂·6H₂O. Luminescent property investigations indicate that compound 1 was applied as the fluorescent probe for the toxic Hg²⁺ ions detection. The evaluation of its anti-cancer activity against the pancreatic cancer was performed and its corresponding mechanism also was explored. Firstly, the Cell Counting Kit-8 was employed for the investigation of the compound’s inhibitory activity on the viability of cancer cell. Moreover, the invasion and migration of cancer cells were detected through exploiting the trans-well assay.

Keywords: Zn(iii) compound; Interdigitated framework; Topology; Luminescence sensing; pancreatic cancer

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-021-01706-8

Chemical Papers 75 (9) 4741–4748 (2021)