ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Concentration-dependent SERS profile of olanzapine on silver and silver-gold metallic substrates

Jamelah S. Al-Otaibi, Paweł Albrycht, Y. Sheena Mary, Y. Shyma Mary, and Monika Księżopolska-Gocalska

Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia

E-mail: marysheena2018@rediffmail.com

Received: 4 March 2021  Accepted: 8 July 2021

Abstract:

Using nanosized metal substrates, surface-enhanced Raman scattering (SERS) is a tool for improving the Raman signal of biomolecules. For detection, SERS has gained much popularity and an important role in determining chemical composition. In the present study, SERS spectra of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) (MPTB) were investigated on silver and silver-gold metal substrates (SERSitive, Warsaw, Poland) at different concentrations. Also, different chemical and electronic properties are investigated using DFT calculations. The ring and other functional modes in SERS change in frequency values with variations in intensity for all concentrations. The molecule is oriented in a tilted manner with respect to Ag and Ag-Au.

Keywords: DFT; SERS; Benzodiazepine; Metal substrates; Ag; Ag-Au

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-021-01783-9

Chemical Papers 75 (11) 6059–6072 (2021)