ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Antiproliferative activity of zinc oxide-silver nanocomposite interlinked with Vaccinium arctostaphylos L. fruit extract against cancer cells and bacteria
Ramin Mohammadi-Aloucheh, Aziz Habibi-Yangjeh, Abolfazl Bayrami, Shima Rahim Pouran, Saeid Latifi-Navid, and Asadollah Asadi
Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
Received: 7 April 2021 Accepted: 1 September 2021
The present study reports the extract-mediated synthesis of ZnO and ZnO/Ag samples using Vaccinium arctostaphylos L. fruit extract. The morphology, microstructure, purity, compositional, structural, and optical characteristics of the fabricated materials were analyzed by various tools. The signature XRD peaks of ZnO and Ag were identified in the patterns and the sizes of the corresponding counterparts were calculated in the EXT/ZnO/Ag10 nanocomposite. As per BET results, the surface areas of the ZnO samples fabricated in water (W/ZnO), fruit extract (EXT/ZnO), and nanocomposite of Ag (EXT/ZnO/Ag10) were 29.3, 27.5, and 25.5 m2g‒1, respectively. The TGA, UV-vis DRS, FT-IR, and EDX analyses explored the integration of the phytochemicals of the studied extract over the prepared samples. Subsequently, the antibacterial, DNA cleavage, and anticancer activities of the samples were, respectively, assessed against S. aureus and E. coli bacteria (using colony forming unit method) and on the MCF-7 cell line (using MTT assay). Among the prepared samples, EXT/ZnO/Ag10 nanocomposite showed superior antibacterial and anticancer activities. The synergistic action of ZnO, Ag, and extract biomolecules of the green-synthesized EXT/ZnO/Ag10 sample against bacteria and cancer cells were thereby suggested. This study introduces a safe and effective bioagent to employ against bacterial and cancerous cells.
Keywords: Biosynthesis; Nanocomposite; Vaccinium arctostaphylos L.; Anticancer; Antibacterial
Full paper is available at www.springerlink.com.
Chemical Papers 76 (1) 247–257 (2022)