ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

New sulfonyl hydrazones and their Pd(II) complexes: synthesis and cytotoxic activities in the MDA-MB-231 cell line

Halime Güzin Aslan

Faculty of Science, Department of Chemistry, Erciyes Üniversity, Kayseri, Turkey

E-mail: guzina@erciyes.edu.tr

Received: 30 June 2021  Accepted: 8 October 2021

Abstract:

In this study, new sulfonyl hydrazone derivatives were synthesized. New sulfonyl hydrazones and their Pd (II) complexes were purified and characterized. Theoretical calculations of the sulfonyl hydrazone materials were done with the B3LYP method in the Gaussian program with the 6–31 (d, p) and 6–311 (d, p) basis sets. The DTA/TG studies investigated at what steps the materials were degraded. Liver tissues were collected from one male and one female healthy albino rats. The effects of the substances on these tissues were examined, and cytotoxic activity results against human breast adenocarcinoma (MDA-MB-231) and human lung epithelial (Beas-2B) were obtained. In the final stage of this study, new sulfonyl hydrazone derivatives Palladium (II) complexes were carried out using LC/MS, ¹H NMR, FT-IR, ¹³C NMR, Magnetic Susceptibility, UV–Vis, Conductivity Measurements. HOMO–LUMO and cytotoxic activities were determined against the human breast adenocarcinoma MDA-MB-231 cell line.

Keywords: DTA/TG; Synthesis; Liver tissue; Wistar albino rat; Cytotoxic activity; Breast cancer MDA-MB-231; Beas-2B; Spartan; Gaussian

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-021-01928-w

Chemical Papers 76 (3) 1413–1421 (2022)