ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis of new thiazolo[2,3-b]pyrimidine derivatives of pharmaceutical interest

Chemistry Department, Faculty of Science, Mansoura University, New Damietta, 34517, Egypt

E-mail: hamada600@yahoo.co.uk

Received: 12 January 2006  Revised: 1 March 2006  Accepted: 3 March 2006

Abstract: 2H-5-Amino-6-cyano-3,7-dioxothiazolo[2,3-b]pyrimidine was subjected to ring formation affording thiazolo[2,3-b]pyrimidine derivatives. 2H-5-Amino-6-cyano-3,7-dioxo-2-phenylmethylenethiazolo[2,3-b]pyrimidine was also subjected to ring formation affording pyrimido[4,5-d]-, pyrano[2,3-d]-, and pyrido[2,3-d]thiazolo[2,3-b]pyrimidine derivatives. 2-Anilinothiocarbonyl-3,9-dioxo-8-imino-7-phenyl-6-thioxothiazolo[2,3-b]pyrimido[4,5-d]pyrimidine and 8-amino-3,9-dioxo-6-thioxothiazolo[2,3-b]pyrimido[4,5-d]pyrimidine reacted with α-haloactive-methylene compounds to afford heterocyclic compounds containing two, fused and isolated, thiazole moieties, respectively.

Keywords: pyrimidine - thiazolo derivatives - ring formation - biological activity

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-006-0046-4

Chemical Papers 60 (4) 268–273 (2006)