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Thiamine-functionalized silver–copper bimetallic nanoparticles-based electrochemical sensor for sensitive detection of anti-inflammatory drug 4-aminoantipyrine

Annum Saeed, Mehwish Akhtar, Sonia Zulfiqar, Farzana Hanif, Ibrahim A. Alsafari, Philips O. Agboola, Sajjad Haider, Muhammad Farooq Warsi, and Imran Shakir

Department of Chemistry, The Govt. Sadiq College Women University, Bahawalpur, Pakistan



Received: 15 September 2021  Accepted: 23 December 2021


In the present manuscript, a highly efficient, sensitive, and selective sensor based on thiamine-modified Ag–Cu bimetallic nanoparticles was designed for trace-level determination of 4-aminoantipyrine (4-AAP). The prepared nanocomposite Th@Ag–Cu was characterized by X-ray diffraction (XRD), UV–visible spectroscopy, and field emission scanning electron microscopy (FESEM). The electrochemical behaviour of 4-APP on the Th@Ag–Cu nanocomposite-modified glassy carbon electrode (GCE) was investigated in 0.1 M NaOH solution by square wave voltammetry (SWV). Compared with the bare GCE, the proposed electrode showed improved analytical signal in detecting 4-AAP. Under optimum experimental parameters, the proposed sensor displayed good linear responses to concentrations ranging from 0.01 to 500 μΜ. The detection limit and sensitivity were calculated as 0.01 and 1.03 μA/μM, respectively. The modified sensing platform exhibited good selectivity, sensitivity and excellent discrimination ability for 4-AAP in the presence of various interfering agents. Moreover, it also offered excellent reproducibility and long-term stability. Hence, the proposed sensor can be a promising candidate for the monitoring of other anti-inflammatory drugs.

Keywords: Ag–Cu NPs; Electrochemical sensor; Thiamine; 4-aminoantipyrine

Full paper is available at

DOI: 10.1007/s11696-021-02042-7


Chemical Papers 76 (5) 2721–2731 (2022)

Tuesday, May 21, 2024

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