ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Development of a fluoremetric probe based on molecularly imprinted polymers for determination of phenobarbital in exhaled breath condensate
Pouya Nasehi Nejhad, Abolghasem Jouyban, Maryam Khoubnasabjafari, Vahid Jouyban-Gharamaleki, Mohamadbahger Hosseini, and Elaheh Rahimpour
Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
Received: 25 October 2021 Accepted: 25 January 2022
In the current study, a fluorometric probe based on molecularly imprinted polymers @ N-doped carbon dots (MIP@N-CDs) is reported for phenobarbital analysis in the exhaled breath condensate collected from the expiratory circuit of the mechanical ventilator (MVEBC). The detection mechanism is based on a charge transfer between N-CDs and phenobarbital that is selectively adsorbed on the active site of MIP. As the decrease in emission intensity is proportional to phenobarbital concentration, a method is proposed for its determination. This method has a linear relationship with phenobarbital concentration in the range of 0.01–8.0 mg L−1 with the relative standard deviation of < 2.0%. The current method is employed for the quantification of phenobarbital in MVEBC of the pre-term newborn babies receiving phenobarbital under a mechanical ventilator.
Keywords: Molecularly imprinted polymers; Phenobarbital; Nanosensor; Exhaled breath condensate
Full paper is available at www.springerlink.com.
Chemical Papers 76 (6) 3447–3457 (2022)