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New protocol for diastereoselective synthesis of spirodihydropyrrole-oxindole derivatives

Robabeh Baharfar, Mohadeseh Verdian, and Saadieh Mohajer

Department of Chemistry, University of Mazandaran, Babolsar, Iran

 

E-mail: Baharfar@umz.ac.ir

Received: 28 March 2021  Accepted: 2 February 2022

Abstract:

A novel approach for diastereoselective synthesis of spiro [indoline-3,2'-pyrrole] derivatives through a three-component reaction of isatin-based ketimines, pyridinium salts, and alkynes in the presence of DABCO under low power microwave. The products were obtained in 70–95% yields in 7–15 min. The advantages of this method consist of environmentally friendly reaction conditions, short reaction times, and good to excellent yields.

Keywords: Spiro [indoline-3,2'-pyrrole]; Microwave; Three-component reaction; Diastereoselective; Isatin-based ketimines; Pyridinium salts

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-022-02121-3

 

Chemical Papers 76 (6) 3809–3815 (2022)

Friday, March 29, 2024

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