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Eco-friendly synthesis and characterizations of Ag/AgO/Ag2O nanoparticles using leaf extracts of Solanum elaeagnifolium for antioxidant, anticancer, and DNA cleavage activities

Mukul Barwant, Yogrsh Ugale, Suresh Ghotekar, Parita Basnet, Van-Huy Nguyen, Shreyas Pansambal, H. C. Ananda Murthy, Mika Sillanpaa, Muhammad Bilal, Rajeshwari Oza, and Vanita Karande

Department of Chemistry, Sanjivani Arts, Commerce and Science College, Savitribai Phule Pune University, Kopargaon, India

 

E-mail: ghotekarsuresh7@gmail.com

Received: 22 November 2021  Accepted: 14 March 2022

Abstract:

The biogenic synthesis of nanoparticles (NPs) using a plant extract is rapid, simple, efficient, cost-effective, and eco-friendly. This study investigated selective pharmacological activities such as anticancer, antioxidant, and DNA cleavage of S. elaeagnifolium-mediated green synthesizing Ag/AgO/Ag2O NPs. To the best of our knowledge, S. elaeagnifolium has been the first time used to synthesize Ag/AgO/Ag2O NPs. The synthesized NPs were explored by using UV–Vis diffuse reflectance spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, high-resolution transmission electron microscopy, energy-dispersive X-ray spectroscopy, and photoluminescence analyses. Anticancer activity of Ag/AgO/Ag2O NPs was tested on lung cancer cell lines (A-549) and showed activity at the IC50 of 67.09 μg/mL. The maximum 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity were 25.78% and 20.86% at 100 µg/L, respectively. Moreover, S. elaeagnifolium-mediated green synthesized Ag/AgO/Ag2O NPs exhibited considerable DNA cleavage activity. These results assured that the synthesized Ag/AgO/Ag2O NPs using S. elaeagnifolium leaves extract may have potential applications in biomedical engineering.

Graphical abstract

Keywords: Green nanotechnology; Solanum elaeagnifolium; Ag/AgO/Ag2O NPs; Biomedical applications

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-022-02178-0

 

Chemical Papers 76 (7) 4309–4321 (2022)

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