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Development and validation of three colorimetric charge transfer complexes for estimation of fingolimod as an antineoplastic drug in pharmaceutical and biological samples

Hesham Salem, Dina Z. Mazen, Dina Heshmat, Mohamed M. Mahmoud, Ebtisam Ali, and Amany Abdelaziz

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New Minia, Egypt

 

E-mail: hesham.salem@deraya.edu.eg

Received: 23 March 2022  Accepted: 15 June 2022

Abstract:

An inexpensive, simple, sensitive and validated approach is developed for estimation of fingolimod through production of colored charge transfer complexes of fingolimod with different electron acceptor reagents, including a reaction of fingolimod as n-donor with 7,7,8,8-tetracyanoquinodimethane, tetrachloro 1,4-benzoquinone and tetracyanoethylene and as n-acceptors, yielding colored and stable anions which were measured spectrophotometrically. The range that obeyed Beer’s law is 50–300 µg mL−1 for fingolimod with all the studied reagents. The various parameters that affect the reaction were studied and optimized. The results were statistically compared with a reported method showing equal precision and accuracy. The researched approaches were utilized to determine the cited drug in its pharmaceutical form and spiked human plasma with accepted accuracy and precision.

Keywords: Fingolimod; TCNQ; TCNE; CL; CTC; Dosage form; Human plasma

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-022-02334-6

 

Chemical Papers 76 (11) 6675–6681 (2022)

Wednesday, June 19, 2024

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