ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Mesoporous nanocarriers with cyclic peptide gatekeeper containing N-cadherin binding sequence for stimulus-responsive drug release

Jeonghun Lee, Kitae Kim, and Chulhee Kim

Department of Polymer Science and Engineering, Inha University, Incheon, Korea

E-mail: chk@inha.ac.kr

Received: 10 March 2022  Accepted: 11 July 2022

Abstract:

Various peptides have been used extensively to prepare selective drug delivery carriers due to the ability to target specific cells and to be selectively degraded by various biostimulants. Furthermore, nanocarriers capable of controlled drug release could be prepared by employing the triggered conformational transformation of peptides by specific biostimulation. Here, a cyclic peptide gatekeeper with an HAV sequence, known to specifically bind to N-cadherin, is introduced on the surface of mesoporous nanocarriers. The drug release from the nanocarriers is completely inhibited in the absence of external stimuli. In the presence of specific biostimuli, the cyclic peptide gatekeeper is transformed, and the encapsulated drugs in the nanocarriers are released on demand.

Keywords: Mesoporous nanocarriers; Stimuli-responsiveness; Peptides; Gatekeepers

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-022-02367-x

Chemical Papers 76 (11) 6801–6807 (2022)