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Efficient synthesis of celecoxib and pyrazole derivatives on heterogeneous Ga-MCM-41-SO3H catalyst under mild condition

Tran Quang-Hung, Tu T. Do, Viet Q. Hoang, Duc M. Tran, Ngo Quoc-Anh, Tuan-Anh L. Hoang, Reinhard Eckelt, Dang V. Do, Tuan T. Dang, and Xuan-Hoan Vu

Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam



Received: 17 May 2022  Accepted: 23 August 2022


The application of Ga-MCM-41-SO3H as a new efficient heterogeneous catalyst for the synthesis of celecoxib and pyrazole derivatives under room temperature is reported. The mesoporous material Ga-MCM-41 was first prepared and then functionalized with the sulfonic acid group by the post-synthetic modification to obtain the final solid acid catalyst. The successful grafting of the -SO3H group onto the Ga-MCM-41 mesoporous walls was asserted by X-ray diffraction, scanning electron microscopy equipped with energy dispersive spectroscopy (SEM/EDS), and acid–base titration. The catalytic application of Ga-MCM-41-SO3H in the synthesis of celecoxib and pyrazole derivatives has resulted in a high yield (up to 95%) under mild conditions. Notably, the Ga-MCM-41-SO3H catalyst was stable and was able to reuse at least five times without losing significant catalytic activity.

Graphical abstract

Keywords: Celecoxib; Pyrazole; Ga-MCM-41-SO3H; Solid acid

Full paper is available at

DOI: 10.1007/s11696-022-02452-1


Chemical Papers 77 (1) 89–99 (2023)

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