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A three-dimensional hybrid of CdS quantum dots/chitosan/reduced graphene oxide-based sensor for the amperometric detection of ceftazidime

Giti Paimard, Mojtaba Shamsipur, and Mohammad Bagher Gholivand

Laboratory of Nanoscale Biosensing and Bioimaging (NBAB), School of Ophthalmology and Optometry, School of Biomedical Engineering, State Key Laboratory of Ophthalmology Optometry, and Vision Science, Wenzhou Medical University, Wenzhou, China



Received: 21 March 2022  Accepted: 14 September 2022


Ceftazidime (CFZ), an anti-bacterial infection drug, was electrochemically investigated at the surface of CdS quantum dots/chitosan/reduced graphene oxide modified glassy carbon electrode (CdS-QDs/CS/rGO/GCE) in pH 3.0 phosphate buffer solution. The modified electrode was described by scanning electron microscopy, Fourier-transform infrared spectroscopy, electrochemical impedance spectroscopy, and cyclic voltammetry. Graphene oxide was synthesized through Hummers’method, which was electrochemically reduced at GCE. CS was used as the introduction of amino groups onto the surface rGO/GCE. The presence of CdS-QDs on the surface of CS/rGO/GCE improved the responded current of the electrooxidation toward CFZ. Under optimized conditions, amperometry in stirred solutions at the practical potential of 0.86 V displayed a linear range of concentration between 15 nM and 95 μM of CFZ. The limit of detection was 4.5 nM. The suggested sensor has high sensitivity and good selectivity for determining CFZ in spiked real samples.

Graphical abstract

Keywords: Ceftazidime; CdS quantum dots; Chitosan; Reduced graphene oxide; Amperometry

Full paper is available at

DOI: 10.1007/s11696-022-02494-5


Chemical Papers 77 (1) 437–449 (2023)

Wednesday, May 22, 2024

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