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Utilizing Fe (III)-doped carbon quantum dots as a nanoprobe for deferiprone determination in exhaled breath condensate

Yasaman Sefid-Sefidehkhan, Mehdi Mokhtari, Abolghasem Jouyban, Maryam Khoubnasabjafari, Vahid Jouyban-Gharamaleki, and Elaheh Rahimpour

Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

 

E-mail: rahimpour_e@yahoo.com

Received: 13 August 2022  Accepted: 22 October 2022

Abstract:

A fluorescence “turn-off” technique was used for the quantification of deferiprone (DEF) in the exhaled breath condensate. Fe (III)-doped carbon dots (CDs) were synthesized with a hydrothermal method as a fluorescent nanoprobe. The prepared Fe (III)-doped CDs selectively and sensitively detect DEF in the concentration range of 0.05–4.0 μg mL−1 using a fluorescence quenching mechanism and with a limit of detection of 0.012 μg mL−1. As DEF acts as a strong iron chelator, the probe has the potential for DEF analysis in the presence of major interfering chemicals. The significant properties of the prepared probe, such as high stability, low cost, quick analysis, and simple operation, make it a helpful tool in bioanalytical chemistry.

Graphical Abstract

A schematic representation of Fe (III)–doped carbon quantum dots as a nanoprobe for deferiprone analysis

Keywords: Deferiprone; Fe(III)-doped carbon quantum dots; Spectrofluorimetry; Exhaled breath condensate

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-022-02563-9

 

Chemical Papers 77 (3) 1445–1453 (2023)

Tuesday, May 28, 2024

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