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Selective oxidation of isoeugenol to licarin A using CuFe2O4 catalysts under mild conditions

Oanh K. Nguyen, Long V. Dang, Son. T. Le, Tung D. Vu, Binh T. Nguyen, Thu T. M. Nguyen, and Dang V. Do

Faculty of Chemistry, VNU University of Science, Viet Nam National University Ha Noi, Hoan Kiem, Ha Noi, Viet Nam



Received: 23 August 2022  Accepted: 3 November 2022


This study reported a new application of CuFe2O4 spinel as an efficient heterogeneous catalyst for the selective oxidation of isoeugenol to licarin A under mild conditions. The CuFe2O4 was prepared via a simple method and characterized by various modern techniques such as X-ray diffraction (XRD), scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDX), and high-resolution transmission electron microscopy (HR-TEM). The XRD and HR-TEM results confirmed the structure and morphology of spinel materials, while the SEM–EDX provided valuable information on the material component. CuFe2O4 catalyst showed excellent catalytic activity in the selective oxidation of isoeugenol to give a high yield of licarin A under mild conditions. In addition, the catalyst was stable and able to reuse at least four times without the loss of catalytic activity.

Graphical Abstract

Keywords: Isoeugenol; Licarin A; CuFe2O4; Selective oxidation; Heterogeneous catalyst

Full paper is available at

DOI: 10.1007/s11696-022-02575-5


Chemical Papers 77 (3) 1583–1591 (2023)

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