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Indium (III)-mediated efficient synthesis and antifungal activity of chromenopyridine scaffolds

Sailam Sri Gogula, Kamalaker Reddy Kamireddy, Saraswathi Meesa, Sunil Misra, Ch. Abraham Lincoln, and P. Muralidhar Reddy

Department of Chemistry, University College of Science, Osmania University, Hyderabad, India

 

E-mail: lincoln.ab86@gmail.com

Received: 1 October 2022  Accepted: 5 April 2023

Abstract:

A novel synthesis of chromenopyridine derivatives has been developed using formyl chromone and β-enaminoester under an indium (III)-mediated approach, which exhibit diverse biological activities. The newly synthesized compounds are characterized and tested for their antifungal activity against the panel of Candida test pathogens. Out of 16 tested compounds, 12 samples exhibited antifungal activity, while four (3c, 3f, 3g and 3n) of them showed good inhibition towards all pathogens. These four samples were further subjected to microbial least inhibition concentration and minimum fungicidal concentration determination; the values were observed between 7.8 and 250 μg/mL towards the selected fungal pathogens.

Keywords: Chromenopyridine; Pyridochromene; Formylchromone; Indium chloride; Antifungal activity

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-023-02821-4

 

Chemical Papers 77 (9) 4823–4829 (2023)

Friday, May 24, 2024

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