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Facile preparation of amino acid-assisted Fe3O4 nanoparticles for low-density lipoprotein cholesterol removal

Nisar Ali Othi, Abdul Hanan, Muhammad Yameen Solangi, Mohamad S. AlSalhi, Sandhanasamy Devanesan, Muhammad Ali Shar, Muhammad Aqeel Bhutto, Muhammad Ishaque Abro, and Umair Aftab

Department of Metallurgy and Materials Engineering, MUET, Jamshoro, Pakistan



Received: 7 July 2023  Accepted: 11 August 2023


Cholesterol is a lipid molecule in protein and cell membrane and precursor of bile acids, steroids hormones and vitamin D. Higher level of cholesterol, especially low-density lipoprotein (LDL), becomes a cause of cardiovascular disease (CVD). Adsorbent of LDL from human blood plasma plays crucial role for the treatment of hyperlipidemia. Therefore, a suitable adsorbent material for efficient and selective adsorption of low-density lipoprotein is beneficial. In this work, amino acids assisted iron oxide (Fe3O4) was synthesized by hydrothermal method. The morphology, size, crystallinity, and chemical attachment of Fe3O4 nanoparticles are characterized by SEM, FESEM/EDS, HRTEM, XRD, XPS, FTIR, and Raman spectroscopy. The lysine-assisted Fe3O4 (Fe3O4-L) nanoparticles have successfully absorbed LDL in plasma, which shows a higher selectivity, as well as attain outstanding adsorption capacity as high as 30.19% within 1 h.

Graphical abstract

Keywords: Fe3O4 nanoparticles; Amino acids; Hydrothermal; Cholesterol removal; LDL

Full paper is available at

DOI: 10.1007/s11696-023-03040-7


Chemical Papers 77 (12) 7749–7759 (2023)

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