ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Dual-adhesive and self-healing alginate-based hydrogel for wound healing

Naglaa Salem El‑Sayed, Naiera M. Helmy, and Samir Kamel

Cellulose and Paper Department, National Research Centre, Giza, Egypt

E-mail: samirki@yahoo.com

Received: 25 July 2023  Accepted: 6 October 2023

Abstract:

Some of the wound dressings on the market cause skin tearing and bleeding when removed, slowing the healing process. So, it is difficult to treat infected wounds of sensitive skin patients. Herein, antibacterial and biocompatibility self-healing hydrogel loaded with 9-Aminoacridine and kanamycin sulfate were prepared by grafting poly(β-carboxyethyl acrylate-co-acrylamide) onto sodium alginate. The biological assay demonstrated the hydrogels’ good biocompatibility, which showed no harmful effects on normal human melanocyte cells. In addition, the hydrogels had a powerful antibacterial impact on the various bacterial strains utilized in the investigation. From the study of the rheological properties of the prepared hydrogel, it was found that it is a non-Newtonian fluid. These results suggest the possible utilization of the as-prepared hydrogels in the fabrication of wound healing.

Keywords: Sodium Alginate; Self-Healing; 9-Aminoacridine; Kanamycin; Interpenetrating and Antimicrobial Hydrogel

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-023-03140-4

Chemical Papers 78 (2) 1021–1031 (2024)