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New homemade NAG-4SX3-3D analyzer for quantification of cyproheptadine hydrochloride by its precipitating with calcium hexacyanoferrate

Bakr Sadiq Mohammed and Nagham Shakir Turkey

Chemistry Department, College of Science, University of Baghdad, Baghdad, Republic of Iraq



Received: 19 September 2023  Accepted: 18 October 2023


The present study employed the NAG-4SX3-3D analyzer to precisely measure the energy response of the sensor. The goal was to enhance the understanding of this technology by providing expert information about the device. This technology offers an economical, quick, accurate, and sensitive approach. By utilizing the turbidity method, Cyproheptadine hydrochloride (CPH) was quantified in pharmaceutical samples without the need for additional substances. CPH is expected to undergo a direct reaction with calcium hexacyanoferrate, resulting in the formation of white precipitates. The linear range for CPH measurement falls within the range of (0.008–30) mM. The relative standard deviation (RSD) for six repetitions at concentrations of (6 and 16) mM was found to be significantly less than 0.22%. The limit of detection (LOD) is 187.381 ng/analyte, calculated from the lowest concentration on the calibration graph through a progressive dilution. The correlation coefficient (r) from the linear dynamic range is 0.9991, with a linearity percentage (R2%) of 99.83. A comparison of the outcomes of the proposed method with an earlier technique (UV spectrophotometric at λmax of 274 nm) revealed them to be similar. However, the proposed procedure is more sensitive, requires fewer reagents, and yields superior results compared to the standard reference technique that employs 10 mM irradiation. It is worth noting that this technology is more sensitive but also requires a higher material consumption.

Keywords: Cyprohetadine hydrochloride; Calcium hexacyanoferrate; NAG-4SX3-3D analyzer

Full paper is available at

DOI: 10.1007/s11696-023-03165-9


Chemical Papers 78 (2) 1277–1290 (2024)

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