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Synthesis and characterization of Fe(III) chitosan nanoparticles n-benzaldehyde Schiff base for biomedical application

Gift Iyobosa Okunzuwa, Omamoke O. E. Enaroseha, and Samuel Ikponmwosa Okunzuwa

Department of Chemistry, Faculty of Physical Sciences, University of Benin, Benin City, Nigeria



Received: 24 June 2023  Accepted: 5 January 2024


Chitosan, chitosan nanoparticles, chitosan nanoparticles n-benzaldehyde Schiff base, and Fe(III) chitosan nanoparticles n-benzaldehyde Schiff base were produced and characterized by Fourier transform infrared spectroscopy, X-ray diffractogram. Fe(III) chitosan nanoparticles n-benzaldehyde Schiff base was biologically evaluated for biomedical application as antimicrobial agent with three gram-positive bacteria: Bacillus subtilis, Bacillus cereus, and Staphylococcus aureus, two gram-negative bacteria: Semolina and Pseudomonas aeruginosa and two fungi: Candida albicans and Aspergillus niger, the activities of Fe(III) chitosan nanoparticles n-benzaldehyde Schiff base were compared with standard drugs. The FTIR spectroscopy results confirm the formation of all the prepared materials. The XRD patterns confirm the crystallinity nature of chitosan and change in crystallinity of chitosan derivatives. The antimicrobial activity of Fe(III) chitosan nanoparticles Schiff base against bacteria and fungi tested showed that the material is a good antimicrobial agent.

Keywords: Chitosan nanoparticles; Schiff base; Antimicrobial agent; Antibiotic Sensitivity; Standard drugs

Full paper is available at

DOI: 10.1007/s11696-024-03309-5


Chemical Papers 78 (5) 3253–3260 (2024)

Tuesday, May 21, 2024

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