ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Development of PEG-coated iron oxide nanoparticles for the oxidation of adrenaline

Kashif Raees, Mohd Shaban Ansari, Mohammad Shahadat, Mohammad Omaish Ansari, and Ammar A. Melaibari

Department of Chemistry, Chandigarh University, Mohali, India

E-mail: mdshahadat93@gmail.com

Received: 22 October 2023  Accepted: 26 February 2024

Abstract:

The present study reports the autoxidation of adrenaline to adrenochrome using polyethylene glycol coated iron oxide nanoparticles (PEG-IONPs) in hydrogen peroxide presence. The influence of PEG with different molecular weights has been studied for the oxidation of adrenaline. A slightly modified co-precipitation method was employed to synthesize PEG-IONPs that were characterized using TEM, XRD, FTIR, TGA, and VSM analyses. Oxidation rate of adrenaline was examined with bare-IONPs and PEG-IONPs using H₂O₂in aqueous and surfactant media. Cetyltrimethyl ammonium bromide (CTABr), sodium dodecyl sulphate (SDS), and Triton X-100 (TX100) were used at premicellar concentrations. The existence of PEG on the surface of IONPs decreased the rate of reaction. Also, the improvement in molecular weight of PEG further declined the reaction rate. The addition of surfactants increased the oxidation rate in the copresence of bare-IONPs, however, decreased the rate with increasing molecular weight of the polymer. Thus, higher molecular weight PEG-supported PEG-IONPs could be used to decrease the oxidation of adrenaline.

Keywords: PEG-coated iron oxide nanoparticles; Autoxidation of adrenaline; Fenton reaction; CTAB; SDS; Triton X-100

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-024-03393-7

Chemical Papers 78 (7) 4317–4327 (2024)