ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Drug carriers in the delivery and release of hydroxychloroquine by biopolymer

Mohammed Kassim Al-Hussainawy and Layth S. Jasim Al-Hayder

Scientific Research Center, National University of Science and Technology, Nassiriya, Iraq

E-mail: Kassim1316@gmail.com

Received: 8 October 2022  Accepted: 13 April 2024

Abstract:

The successful development of several unique and intelligent drug delivery systems, characterized by enhanced therapeutic effectiveness and improved patient compliance, underscores the ongoing advancements and research in the realm of biopolymers, guiding cost-effectiveness. Various biodegradable polymers find widespread use in the drug delivery industry due to their ability to break down biologically inside the body into non-toxic components. A comprehensive understanding of the potential qualities of biopolymers is crucial for designing diverse drug delivery systems. This includes insights into extraction techniques, environmentally friendly manufacturing processes, chemistry, surface properties, rheology, bulk properties, biocompatibility, and biodegradability. As a response to these demands, novel biopolymers were synthesized using free radicals and cross-linked molecules, and their physical and chemical properties were thoroughly investigated. Several analytical techniques, such as FT-IR-EDX, XRD, SEM, TEM, TGA, and BET-BJH, were employed to conduct comprehensive examinations. The results demonstrated favorable adsorption and release of the adsorbed drug into the aqueous solution, with a percentage of 20% at pH 2 and 3% at pH 7. Notably, the dissolution rate was observed to be high in the presence of varying concentrations of salt. This research signifies a significant contribution to the field, as it provides valuable insights into the properties and potential applications of newly synthesized biopolymers in drug delivery systems. The successful outcomes in adsorption and release highlight the promise of these biopolymers in improving therapeutic outcomes and patient experiences.

Keywords: Biopolymer; Drug delivery; Polysaccharides; Copolymer of alginate-carrageenan; Environmental protection

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-024-03463-w

Chemical Papers 78 (9) 5255–5266 (2024)