ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Biological impacts of imidazoline derivatives

Arup K. Kabi, Raghuram Gujjarappa, Virender Singh, and Chandi C. Malakar

Department of Chemistry, National Institute of Technology Manipur, Imphal, India

E-mail: cmalakar@nitmanipur.ac.in

Received: 18 October 2022  Accepted: 30 April 2024

Abstract:

Imidazolines, also known as dihydroimidazolines, are an important class of aromatic five-membered heterocycles that include two nitrogen atoms. Imidazolines are present in a wide range of biologically active natural and synthetic compounds. The synthesis of imidazoline-containing drugs has expanded dramatically after the findings of the imidazoline binding site (IBS) in 1984. Furthermore, many substituted imidazolines have shown potential therapeutic efficacy in the treatment of a variety of disorders, including anthelmintics, antifungal, anticancer, hypertension, and hyperglycemia, as well as Parkinson's and Alzheimer's diseases. Moreover, chiral imidazolines are extensively used as organocatalysts in the synthesis of a wide range of natural and synthetic organic molecules. This overview highlights the different pharmacological and biological activities of imidazolines derivatives.

Keywords: Imidazoline; N-heterocycles; Pharmacophore; Drug discovery; Insulin secretion

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-024-03496-1

Chemical Papers 78 (10) 5743–5752 (2024)