ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis, characterization and biological activity studies of Pd(II) and Pt(II)–2H-benzo[e][1,3]oxazine-2,4(3H)-dione (HBzoxe) complexes

Wesam H. Khalaf, Subhi A. Al-Jibori, Muhammad Ashfaq, Ahmed S. Faihan, Muhammad Nawaz Tahir, and Ahmed S. M. Al-Janabi

Department of Chemistry, College of Science, Tikrit University, Tikrit, Iraq

E-mail: dr.ahmed.chem@tu.edu.iq

Received: 25 March 2024  Accepted: 8 August 2024

Abstract:

Mixed-ligand complexes of Pd(II) and Pt(II) with 2H-benzo[e][1,3] oxazine-2,4(3H)-dione (HBzoxe), tertiary phosphines (dppe, dppp, dppf and Ph₃P), 2,2′-bipyridine (Bipy) and 1,10-phenanthroline (Phen) have been synthesized and characterized by molar conductance measurements, elemental analysis, IR and NMR (¹H, ¹³C and ³¹P) spectroscopy. In addition, the antimicrobial activity assay studies. The results showed that the HBzoxe ligand behaves as a bidentate chelation ligand through the O and N atoms in [M(Bzoxe)₂] {M^II = Pd(1) and Pt(2)} complexes, whereas it acts as monodentate ligand through the oxygen atom in complexes (3–14) to afford a square planner geometry around Pd(II) and Pt(II) for all of the complexes. All of the complexes were moderately active on all the bacteria tested (Staphylococcus aureus and Escherichia coli). Hirshfeld surface analysis was carried out to investigate the cooperative non-covalent supramolecular interactions within the various complexes.

Keywords: Oxazine; Phosphine; Amine; Complexes; Palladium; Platinum

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-024-03650-9

Chemical Papers 78 (14) 7987–7998 (2024)