In vivo and in vitro evaluations of functionalized mesoporous silicaArdeshir Shokrollahi, Ali Mirzaei, Forough Karami, Sarina Salimpour, Aida Shafe, and Shiva Shokrollahi Department of Chemistry, Yasouj University, Yasouj, Iran
E-mail: ashokrollahi@yu.ac.ir Received: 6 February 2024 Accepted: 21 August 2024 Abstract: The mobile crystalline material-41 (MCM-41) has been used in various fields, such as measuring cations, dye removal, and drug delivery. Modification of MCM-41 improves some properties of mesoporous materials, including surface area, adsorption capacity, thermal stability, and mechanical stability. Considering of these, after synthesize of MCM-41@SiO2-NH-pydc, in vivo and in vitro studies of MCM-41@SiO2-NH-pydc were conducted. For in vitro toxicity, various concentrations of 75, 150, and 300 mg L−1 were used in Allium cepa test to study the toxicity and genotoxicity of mesoporous. For in vivo toxicity, 40 Wistar albino rats were collected and acute toxicity was estimated through oral administration (PO). For the sub-chronic study, four groups of Wistar rats were randomly selected and received MCM-41@SiO2-NH-pydc daily by gavage at dosages of 12.5, 25, and 50 mg kg−1 for 28 days. For hematological and biochemical tests, blood was collected, and the liver and kidney were dissected and prepared as slides to study histopathology. The lethal dose 50 (LD50) of MCM-41@SiO2-NH-pydc was found to be more than 250 mg kg−1. All hematological and biochemical parameters were reported as normal, indicating no serious toxicity. Therefore, based on the findings obtained, it is suggested to use MCM-41@SiO2-NH-pydc as a safe, appropriate, and novel carrier for drug delivery investigations. Keywords: Allium cepa; In vitro; In vivo; MCM-41; Mesoporous; Toxicity Full paper is available at www.springerlink.com. DOI: 10.1007/s11696-024-03665-2
Chemical Papers 78 (15) 8261–8270 (2024) |
Thursday, November 21, 2024 
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