ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Utilizing BN-biphenylene nanosheet as a potential carrier for thioguanine: a promising drug delivery system

Yousef A. Bin Jardan, Yashwantsinh Jadeja, Soumya V. Menon, Debasish Shit, Girish Chandra Sharma, Mounir M. Bekhit, Rasha Ali Abdalhuseen, Salah Hassan Zain Al-Abdeen, and Ruaa Sattar

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

E-mail: ruaasattarr@gmail.com

Received: 25 March 2024  Accepted: 10 February 2025

Abstract:

A substantial amount of research has been conducted on the development of innovative systems for drug delivery. This study explores the use of boron nitride biphenylene network (BPN–BN) as a BPN analog of biphenyl. DFT calculations were undertaken for examining the interactions between BPN–BN and thioguanine (THG), which is an anticancer drug. The THG/BPN–BN system was found to exhibit chemical reactivity, making it ideal for the bonding of THG with the adhesive site. Additionally, the non-covalent interaction analysis was conducted to understand the complexes of THG with BPN–BN, revealing that the interactions between THG and BPN–BN were strong. Consequently, it was confirmed that BPN–BN has the potential to serve as a potential nanocarrier for THG.

Keywords: BN-biphenylene nanosheet; Drug delivery systems; Thioguanine; Nanocarrier

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-025-03956-2

Chemical Papers 79 (4) 2531–2540 (2025)