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Multicomponent facile synthesis of novel dihydroazolopyrimidinyl carbamides

E. Gladkov, S. Sirko, B. Khanetskii, E. Lukinova, and S. Desenko

State Scientific Institution “Institute for Single Crystals”, National Academy of Sciences of Ukraine, Lenin Ave. 60, 61001 Kharkov, Ukraine

 

E-mail: gladkov@isc.kharkov.com

Received: 19 September 2006  Accepted: 26 October 2006

Abstract: Number of novel derivatives of dihydrotriazolo-and-tetrazolopyrimidines containing carboxamide group in position 6 were obtained by multicomponent Biginelli-type reaction. The structures of all synthesized compounds were proved by NMR and MS spectral methods. The method of three-component Biginelli-type reaction is well suited for the synthesis of new promising dihydroazolopyrimidines providing a scaffold for screening of biological activity.

Keywords: nitrogen heterocycles - dihydropyrimidines - multicomponent reactions - cyclocondensation

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-007-0012-9

 

Chemical Papers 61 (2) 146–149 (2007)

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