ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7

Published monthly
 

Development of the Analytical Method for LC-MS Detection of Unknown Degradation Product of Alprazolam

L. Hanyšová, T. Grafnetterová, M. Dubovská, and J. Klimeš

Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, CZ-500 05 Hradec Králové, Czech Republic

 

E-mail: hanysova@faf.cuni.cz

Received: 14 November 2003

Abstract: The stability of alprazolam ms a pure substance and in the tablets was studied. The gradient HPLC chromatographic conditions were described for LC-MS identification of an impurity. Employing this chromatographic method, the stability of alprazolam under conditions of dry and wet heat was observed. The unknown degradation product was identified using MS detection.

Full paper in Portable Document Format: 592a99.pdf

 

Chemical Papers 59 (2) 99–102 (2005)

Saturday, June 15, 2024

IMPACT FACTOR 2021
2.146
SCImago Journal Rank 2021
0.365
SEARCH
Advanced
VOLUMES
European Symposium on Analytical Spectrometry ESAS 2022
© 2024 Chemical Papers