ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis and Biological Evaluation of Some New Fused Heterobicyclic Derivatives Containing 1,2,4-Triazolo/1,2,4-Triazinopyridinone Moieties

W. R. Abdel-Monem

Department of Chemistry, Faculty of Education, Ain-Shams University, 11711 Roxy, Cairo, Egypt

E-mail: wafaar@hotmail.com

Received: 18 December 2002  Revised: 23 April 2004

Abstract: Syntheses of fused heterobicyclic systems containing 1,2,4-triazolo/1,2,4-triazinopyridinone moieties were accomplished by heterocyclization of 4-(4-chlorophenyl)-1,6-diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile (III ) or 6-amino-4-(4-chlorophenyl)-2-oxo-1-(5,6-diphenyl-1,2,4-triazin-3-ylamino)-1,2-dihydropyridine-3,5-dicarbonitrile (XII) with α,β-bifunctional oxygen and halooxo compounds in different media in order to establish a relation between structure and their activities. Compounds III and XII which contain 1,2-biamino group are more favoured to the ringclosure reactions. Structure assignments of new products have been established on the basis of elemental analysis and spectral data. The antimicrobial activity of the products has been also evaluated where some compounds showed a better activity against selected tested microbes in comparison with control.

Full paper in Portable Document Format: 584a276.pdf

Chemical Papers 58 (4) 276–285 (2004)