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Chemistry of Substituted Quinolinones I. Synthesis of Novel Triazinylmethylquinolinone Derivatives

M. Abass and M. M. Ismail

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy 117711, Cairo, Egypt

 

E-mail: mabass66@netscape.net

Abstract: Functionalization of 1H-quinolin-2-one moiety, at the position 3, with pyruvic or 2-thiopyruvic acid substrates, in order to develop novel synthons of heterocyclic derivatives of quinolinone, was achieved through ring-closure and ring-opening routes. The syntheses of some new 3-([1,2,4]triazin-6-ylmethyl) quinolines have been described. Three multiaza-polynuclear heterocycles, viz. triazinophthalazine, triazinoindole, and bistriazinoquinoxaline, were also synthesized and are expected Go have biological importance. The structures of all new products were verified on the basis of their elemental and spectral analyses.

Full paper in Portable Document Format: 543a187.pdf

 

Chemical Papers 54 (3) 187–195 (2000)

Wednesday, May 29, 2024

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