ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
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Synthesis of Some New Piperazine-N´N'-bis-substituted Derivatives As Potential Biologically Active Agents

S. G. Abdel-Hamide, H. M. El-Shaaer, H. A. Allimony, S. A. Abdel-Aziz, and R. A. Abdel-Rahman

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alazhar University, Cairo, Egypt


Abstract: In a search for new bactericidal and fungicidal agents some new piperazine-N,N'-bis-substituted derivatives have been prepared and characterized by their elemental analysis, IR, 1H NMR, and mass spectral data. The antibacterial and antifungal activities of all prepared compounds have been determined using Gentamycin as standard antibiotic. Some compounds showed a high activity equivalent to that of the standard towards Escherichia coli, Serratia marcescens, Bacillus cereus, Staphylococcus aureus, and Candida albicans.

Full paper in Portable Document Format: 493a142.pdf


Chemical Papers 49 (3) 142–148 (1995)

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