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Influence of Structure on Antimicrobial Activity of Some Heterocycies.4. 1 -(3-Alkylamino-2-hydroxypropyl)-2-methyl-5-nitroimidazoles

M. Koóš, B. Steiner, and Z. Novotná

Institute of Chemistry, Slovak Academy of Sciences, SK-842 38 Bratislava

 

Abstract: Several 1-(3-alkylamino-2-hydroxypropyl)-2-methyl-5-nitroimidazoles were prepared by the ring-opening displacement reaction of 1-(2,3-epoxypropyl)-2-methyl-5nitroimidazole with some amines. The structure of the prepared compounds was confirmed on the basis of IR, mass, NMR spectral data and elemental analysis. Antimicrobial activity of these compounds against selected bacteria and fungi was also determined. No significant effects were found in this respect.

Full paper in Portable Document Format: 481a54.pdf

 

Chemical Papers 48 (1) 54–57 (1994)

Monday, August 08, 2022

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