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A Convenient Route for Synthesis of 1,2,4-Triazolines as Substituents to Benzo[f]-4-hydroxy-152-dihydro-2- quinolone

E. A. Mohamed

Department of Chemistry, Faculty of Education, Ain-Shams University, Roxy, Cairo, Egypt

 

Abstract: Benzo[f]-3-[(p-chlorophenylamino)(hydrazino)methyl]-4-hydroxy-1,2-dihydro-2-quinolone was prepared by the addition of HBr on -CH=N bond of the Schiff base followed by condensation with hydrazine and was used in the synthesis of different substituted triazolines borne on a quinolone moiety giving rise to a system of high probability to be of great biological importance. Some other derivatives of this class of compounds of expected pharmaceutical importance were obtained by the action of certain nucleophiles as well as by alkylation of the respective triazoline. The structures of the obtained compounds were elucidated by IR and H-1 NMR spectroscopy.

Full paper in Portable Document Format: 484a257.pdf

 

Chemical Papers 48 (4) 257–261 (1994)

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