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Some New Quinolones of Expected Pharmaceutical Importance Derived from 1,2-Dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carbaldehyde

E. A. Mohamed

Department of Chemistry, Faculty of Education, Ain-Shams University, Roxy, Cairo, Egypt


Abstract: The title compound was condensed with various amino derivatives giving rise to new quinolones of expected biological activity, especially the condensation products of thiosemicarbazide and its derivatives. For the purpose of inducing and/or improving the pharmaceutical importance of the latter products, they were subjected to certain cyclization reactions, affording new quinolones substituted with heterocyclic rings. The structures of certain other new quinolones were elucidated by preparing them by two different routes, using interesting reagents. Condensation of 1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline with certain compounds having active methylene groups was also studied.

Full paper in Portable Document Format: 484a261.pdf


Chemical Papers 48 (4) 261–267 (1994)

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