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Synthesis of Some Multiazaheterocycles as Substituents to Quinolone Moiety of Specific Biological Activity

E. A. Mohamed, M. M. Ismail, Y. Gabr, and M. Abass

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt


Abstract: New Schiff bases, hydrazones and semicarbazones derived from 1,2-dihydro-4-hydroxy-6-methyl-2-oxoquinoline-3-carbaldehyde, have been synthesized. The semicarbazone was subjected to react with 2,3-dichloroquinoxaline, chloroacetic acid, and oxalyl chloride affording multiazaheterocycles substituted to quinolone moiety at position 3. Condensation of the 2-imidazolidine-thione derivative with some amines and hydrazines yielded some new heterocyclic systems of expected biological activity. Some of these imine derivatives were tested for their bactericidal, fungicidal, and molluscicidal activities. The structures of all new quinolone derivatives have been characterized by chemical reactions and physical tools.

Full paper in Portable Document Format: 484a285.pdf


Chemical Papers 48 (4) 285–292 (1994)

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