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Kinetics of alkaline hydrolysis of heptacaine chloride basic analogs

M. Stankovičová, J. Čižmárik, and M. Bachratá

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, CS-832 32 Bratislava

 

Abstract: Kinetics of alkaline hydrolysis have been studied with a series of six basic analogues of heptacaine chloride (N-{2-[N-(2-heptyloxyphenyl)carbamoyl- oxy]ethyl}piperidinium chloride) in aqueous-ethanolic solution of 0.1 M-NaOH at 40, 50, and 60 °C. The rate constants and the activation pa­rameters EA , ∆H  and ∆ S have been calculated. pKa Values of the studied substances have been determined titrimetrically and have been correlated with the obtained rate constants.

Full paper in Portable Document Format: 442a171.pdf

 

Chemical Papers 44 (2) 171–176 (1990)

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