ISSN print edition: 0366-6352
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Retention indexes of some  ß-adrenolytics and their perfluoroacyl derivatives

V. Marko

Institute of Experimental Pharmacology, Centre of Physiological Sciences, Slovak Academy of Sciences, CS-842 16 Bratislava


Abstract: Retention indices (RI) of 10  ß-adrenolytics and their trifluoroacetyl and heptafluorobutyryl derivatives on columns with nonpolar OV1 and moderately polar OV 17 stationary phases, respectively, have been studied. The retention indices of the original drugs on the OV 1 phase ranged from 1721 to 2795 and on the OV 17 phase from 1939 to 3290. By derivatization the differences in RI values in the systems with different stationary phases decreased and so did the differences in values obtained in different laborato­ ries.

Full paper in Portable Document Format: 423a375.pdf


Chemical Papers 42 (3) 375–380 (1988)

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