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ISSN electronic edition: 1336-9075
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HPLCdetermination of chlorhexidine in dosage forms

K. BeneŇ° and Z. Pavelek

Galena, n.e., CS-747 70 Opava

 

Abstract: The present paper describes the utilization of high-pressure liquid chromatography for determination of Chlorhexidine in complex samples of dosage forms. Chromatographic separation was performed on a cyanopropyl column using acetate buffer in the mixture of water and acetonitrile ( φr = 2:3) as the mobile phase. The linear dependence of the peak size on concentration of Chlorhexidine in the range of 0.01 to 0.20 mol m-3 was ensured only when the samples were diluted with the mobile phase. Otherwise, the reproducibility of measurements decreased substantially.

Full paper in Portable Document Format: 425a601.pdf

 

Chemical Papers 42 (5) 601–606 (1988)

Wednesday, June 19, 2024

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