ISSN print edition: 0366-6352
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Synthesis of some substituted tetrazolylacetic acids

Ľ. Janda and Z. Votický

Drug Research Institute, CS-90001 Modra

 

Abstract: 5-[5-(Substituted phenylthio)-2-furyl]tetrazol-l-ylacetic acids were pre­pared from ethyl 5-(substituted phenylthio)-2-furylcarbamidoacetates and phosphorus pentachloride via the corresponding imidoyl chlorides, which on treatment with sodium azide afforded the appropriate ethyl 5-[5-(substituted phenylthio)-2-furyl]tetrazolylacetates. Free acids serving as an inter­mediate in preparation of semisynthetic cephalosporins were obtained by an alkaline hydrolysis.

Full paper in Portable Document Format: 415a643.pdf

 

Chemical Papers 41 (5) 643–654 (1987)

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