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Benzothiazole compounds. 27. Alkylation and antifungal activity of some 2-R-3-(2-mercaptoethyl)benzothiazolines

S. Mikulášek, V. Sutoris, A. Perjéssy, and P. Foltínová

Department of Organic Chemistry, Faculty of Natural Sciences, Komenský University, CS-842 15 Bratislava

 

Abstract: The series of 2-R-3-(2-R'-thioethyl)benzothiazolines and allyl esters of bis[2-(2-R-3-benzothiazolinyl)ethylthio]acetic acid were synthesized by alkylation of 3-(2-mercaptoethyl)-2-benzothiazolinone oxime, 3-(2-mercaptoethyl)-2-benzothiazolinone semicarbazone, and 3-(2-mercaptoethyl)-2-benzothiazolinone thiosemicarbazone with corresponding reactive compounds. The structures of prepared compounds were confirmed by infrared spectra. The antibacterial activity of compounds is rather low, however the results of the antifungal tests showed more favourable results.

Full paper in Portable Document Format: 406a779.pdf

 

Chemical Papers 40 (6) 779–790 (1986)

Tuesday, May 21, 2024

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