ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

A new phenanthroindolizidine alkaloid from Tylophora indica

Mini Dhiman, Amit Khanna, and Sreedharannair L. Manju

Special Projects Analytical Chemistry, Piramal Healthcare Ltd. 1, Goregaon (E), 400063, Mumbai, India

E-mail: minidhiman@gmail.com

Abstract: A new phenanthroindolizidine alkaloid, 3-O-demethyl tylophorinidine (VI), was isolated from the aerial (leaves and stem) parts of Tylophora indica and characterized using different spectral techniques. Gel chromatography and reverse phase preparative HPLC were used for sample purification. The new alkaloid, VI, was screened for anticancer activity against a panel of different cancer cell lines and it showed significant anticancer activity with IC₅₀ value in the range of 0.89–1.40 μM.

Keywords: Tylophora indica – asclepiadaceae – phenanthroindolizidine alkaloids – anticancer

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-012-0265-9

Chemical Papers 67 (2) 245–248 (2013)