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Study of controlled tetracycline release from porous calcium phosphate/polyhydroxybutyrate composites

Ľ. Medvecký, R. Štulajterová, and J. Briančin

Institute of Materials Research, Slovak Academy of Sciences, SK-043 53 Košice, Slovakia



Received: 21 December 2006  Revised: 2 April 2007  Accepted: 8 June 2007

Abstract: Porous calcium phosphate ceramics were prepared by sintering of mixtures of nanocrystalline apatitic calcium phosphate and fibrous natural cotton cellulose after pressing at temperatures of 1150 °C and 1250 °C. Micro-and macropores were present in microstructures of ceramic samples. The microstructures of porous ceramics were similar to those observed in bone tissues and fiber-like randomly oriented texture was observed in ceramics. Polyhydroxybutyrate (PHB) biopolymer layers are distributed homogeneously in the samples after evaporation of the diluent (chloroform) from the PHB vacuum impregnated porous samples. The tetracycline (TTC) release rate decreases with the content of polyhydroxybutyrate in the ceramic samples, which corresponds to the rise in amount of biopolymer displaced in the pores of ceramics. The concentration of TTC in the phosphate buffer saline solution varies almost linearly with time after the first seven hours from the start of the release of the calcium phosphate ceramic samples with 2.4 mass % of polyhydroxybutyrate. The initial burst effect was significantly depressed by the preparation method used.

Keywords: calcium phosphate - polyhydroxybutyrate - release - tetracycline - ceramics - scaffold

Full paper is available at

DOI: 10.2478/s11696-007-0065-9


Chemical Papers 61 (6) 477–484 (2007)

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